Enhancing Tools for Exploring Complex Signaling Pathways in Developing Xenopus Embryos. Furthermore, the loss of Wnt4 results in convergent and extension (CE) cell movement abnormalities and abnormal Vangl2 localization, suggesting Wnt4's critical role in guiding planar cell polarity. This study will define whether Wnt4 is involved in instructing PCP and how cells transport Wnt4 to regulates PCP. Recent our studies have revealed a link between the spatial and temporal expression of Wnt4 and this progressive PCP acquisition, indicating Wnt4's potential role as an instructive signal. The acquisition of PCP in the neural plate advances from posterior to anterior positions. Earlier research in amphibian vertebrate embryos has proposed that secreted signaling molecules from the dorsal blastopore lip play a crucial role in instructing PCP. However, the contradictory findings, particularly the suggestion that Wnt ligands may not be necessary for establishing PCP in Drosophila wing development, cast doubt on the signals responsible for initiating PCP. These ligands have been implicated in coordinating PCP elements in various events like the closure of the neural tube, the development of fly wings, the formation of cochlear hair cells, and limb development. ![]() Numerous studies have delved into the influence of non-canonical Wnt ligands, specifically Wnt 4, 5, and Wnt 11, on planar cell polarity (PCP) during diverse developmental processes. Exploring the mechanisms that regulate Planar Cell Polarity.
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